BPH stained with Anti-Androgen Receptor
Androgen receptor (AR) is a member of the steroid receptor superfamily that is essential for the growth of prostate cancer cells. AR antibody labels epithelial cells and stromal cells in normal prostate. AR reactivity is also found in other types of cells, including epithelial cells of the breast and hepatocytes. In prostate cancer, AR expression is maintained throughout cancer progression. Immunohistochemistry of AR is useful for the evaluation of prostate cancer in routinely processed tissues. The majority of androgen independent hormone refractory prostate cancers express AR. Transcriptional activation of AR is involved in refractory anti-androgen therapy. Androgen receptor expression has been helpful in predicting the clinical response to anti-androgenic treatment.
Androgen receptor (AR) is a member of the steroid receptor superfamily that is essential for the growth of prostate cancer cells. AR antibody labels epithelial cells and stromal cells in normal prostate. AR reactivity is also found in other types of cells, including epithelial cells of the breast and hepatocytes. In prostate cancer, AR expression is maintained throughout cancer progression. Immunohistochemistry of AR is useful for the evaluation of prostate cancer in routinely processed tissues. The majority of androgen independent hormone refractory prostate cancers express AR. Transcriptional activation of AR is involved in refractory anti-androgen therapy. Androgen receptor expression has been helpful in predicting the clinical response to anti-androgenic treatment.
