ALK-1A4

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, a hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumors including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumorigenesis, including ALK(chromosome 2), EML4(chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG(chromosome 3), ALK/NPM1(chromosome 5), ALK/SQSTM1(chromosome 5), ALK/KIF5B(chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome  X).

• Source
  Mouse Monclonal
• Clone
  1A4
• Class
  IVD
• Isotype
  Mouse IgG2b
• Tested Reactivity
  Human, FFPE
• Localization
  Cytoplasm/Nucleus
• Positive Control
  Anaplastic large cell lymphoma

• Catalog
  Pack Size
• PM158-3ml
  3 ml(RTU)
• PM158-6ml
  6 ml(RTU)
• CM158-0.1ml
  0.1 ml(Conc.)
• CM158-0.5ml
  0.5 ml(Conc.)
• HAM158-3ml
  3 ml(RTU)
• HAM158-6ml
  6 ml(RTU)
• CM158 - 1ml
  1ml ( Conc. )