In normal tissues, cytokeratin (high molecular weight) is mainly expressed in normal squamous epithelium, ductal epithelium and other laminated epithelium. Positive expression was found in lung squamous cell carcinoma, breast cancer, pancreatic cancer, cholangiocarcinoma and bladder transitional cell carcinoma.Anti-cytokeratin, high molecular weight is capable of recognizing all basic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. Members of the acidic and basic subfamilies are found together in pairs. Since each epithelium contains at least one acidic and one basic keratin, this antibody is used to observe the distribution of keratin-containing cells in normal epithelia and to identify neoplasms derived from such epithelium.
In normal tissues, cytokeratin (high molecular weight) is mainly expressed in normal squamous epithelium, ductal epithelium and other laminated epithelium. Positive expression was found in lung squamous cell carcinoma, breast cancer, pancreatic cancer, cholangiocarcinoma and bladder transitional cell carcinoma.Anti-cytokeratin, high molecular weight is capable of recognizing all basic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. Members of the acidic and basic subfamilies are found together in pairs. Since each epithelium contains at least one acidic and one basic keratin, this antibody is used to observe the distribution of keratin-containing cells in normal epithelia and to identify neoplasms derived from such epithelium.
