CD45 leukocyte common antigen(LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic tissues. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential identification of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
CD45 leukocyte common antigen(LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic tissues. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential identification of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.