Caldesmon is a smooth muscle regulatory protein that interacts with actin, myosin, tropomyosin and calmodulin. It is more specific to smooth muscle differentiation than desmin and muscle specific actin. Also, it is useful in differentiation of smooth muscle from myofibroblast tumors and uterus leiomyoma from endometrial stroma tumor. Caldesmon is a marker for identification of epitheloid mesothelioma.
Caldesmon is a smooth muscle regulatory protein that interacts with actin, myosin, tropomyosin and calmodulin. It is more specific to smooth muscle differentiation than desmin and muscle specific actin. Also, it is useful in differentiation of smooth muscle from myofibroblast tumors and uterus leiomyoma from endometrial stroma tumor. Caldesmon is a marker for identification of epitheloid mesothelioma.