HER2/ErB2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinase. The kinase activity of ErbB2 can be activated without a ligand if it is overexpressed, and by association with other ErbB proteins. Overexpression of ErbB2 is detected in almost 40% of human breast cancers.
HER2/ErB2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinase. The kinase activity of ErbB2 can be activated without a ligand if it is overexpressed, and by association with other ErbB proteins. Overexpression of ErbB2 is detected in almost 40% of human breast cancers.