CD23, a type II transmembrane glycoprotein, is a key molecule for B-cell activation and growth functions as a receptor for IgE. CD23 antibody labels activated B-cells expressing IgM/IgD and follicular dentritic cells. In tumors, CD23 antibody is helpful in identification of B-cell chronic lymphocytic leukemia (CLL), follicular dendritic cell tumors, and mediastinal large B-cell lymphoma. In addition, anti-CD23 is useful to differentiate CLL from mantle cell lymphoma which is CD23 negative.
CD23, a type II transmembrane glycoprotein, is a key molecule for B-cell activation and growth functions as a receptor for IgE. CD23 antibody labels activated B-cells expressing IgM/IgD and follicular dentritic cells. In tumors, CD23 antibody is helpful in identification of B-cell chronic lymphocytic leukemia (CLL), follicular dendritic cell tumors, and mediastinal large B-cell lymphoma. In addition, anti-CD23 is useful to differentiate CLL from mantle cell lymphoma which is CD23 negative.