CD103, also known as integrin alpha E (ITGAE) is an integrin protein that in humans is encoded by ITGAE gene. It binds integrin beta 7 to form the complete heterodimeric molecular αEβ7 that binds to an extracellular matrix component and cellular counter receptor.They mediate cell adhesion,migration and signaling and are important for T-lymphocyte localization.CD103 is expressed on intraepithelial lymphocytes in mucosal areas, including lung and GI tract. In malignancies, CD103 is present on all enteropathy-type T-cell lymphomas. Additionally, CD103 has been a useful maker for hairy cell leukemia.
CD103, also known as integrin alpha E (ITGAE) is an integrin protein that in humans is encoded by ITGAE gene. It binds integrin beta 7 to form the complete heterodimeric molecular αEβ7 that binds to an extracellular matrix component and cellular counter receptor.They mediate cell adhesion,migration and signaling and are important for T-lymphocyte localization.CD103 is expressed on intraepithelial lymphocytes in mucosal areas, including lung and GI tract. In malignancies, CD103 is present on all enteropathy-type T-cell lymphomas. Additionally, CD103 has been a useful maker for hairy cell leukemia.