ATRX plays a role in chromatin regulation and maintenance of telomeres. It regulates incorporation of histone H3.3 into telomeric chromatin. ATRX is also a major component of various essential cellular pathways such as DNA replication and repair, chromatin higher-order structure regulation, gene transcriptional regulation, etc. ATRX loss was observed in grades II/III astrocytomas, oligoastrocytomas, oligodendrogliomas, and glioblastomas. Assessment of ATRX loss by immunohistochemical staining captures the majority of mutations, indicating that the use of immunohistochemical testing in routine neuropathology diagnostics gives a reasonable sensitivity.
ATRX plays a role in chromatin regulation and maintenance of telomeres. It regulates incorporation of histone H3.3 into telomeric chromatin. ATRX is also a major component of various essential cellular pathways such as DNA replication and repair, chromatin higher-order structure regulation, gene transcriptional regulation, etc. ATRX loss was observed in grades II/III astrocytomas, oligoastrocytomas, oligodendrogliomas, and glioblastomas. Assessment of ATRX loss by immunohistochemical staining captures the majority of mutations, indicating that the use of immunohistochemical testing in routine neuropathology diagnostics gives a reasonable sensitivity.