Urothelial Ca stain with anti UROPLAKIN-III
Uroplakin III glycoprotein is present in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. Uroplakins are expressed in the luminal surface plasmalemma of superficial (umbrella) cells. It plays an important role in asymmetric unit membrane-cytoskeleton interaction in terminally differentiated urothelial cells. Uroplakin III is a highly specific paraffin-reactive immunohistochemical marker for urothelial tumors with a moderate sensitivity for the identification of primary and metastatic urothelial carcinomas.
Uroplakin III glycoprotein is present in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. Uroplakins are expressed in the luminal surface plasmalemma of superficial (umbrella) cells. It plays an important role in asymmetric unit membrane-cytoskeleton interaction in terminally differentiated urothelial cells. Uroplakin III is a highly specific paraffin-reactive immunohistochemical marker for urothelial tumors with a moderate sensitivity for the identification of primary and metastatic urothelial carcinomas.
