Urinary bladder stained with Anti-Uroplakin III
Uroplakin III (UP III) is one of the four transmembrane proteins (UPIa, UPIb, UPII, and UPIII) that are specifically expressed in terminally differentiated urothelial cells.Studies have shown that UPIII is highly specific for identification of primary and metastatic urothelial carcinomas. However, the sensitivity of UPIII in detection of urothelial carcinoma is moderate. Combined use of a panel of antibodies is important in the diagnosis of urothelial tumors.
Uroplakin III (UP III) is one of the four transmembrane proteins (UPIa, UPIb, UPII, and UPIII) that are specifically expressed in terminally differentiated urothelial cells.Studies have shown that UPIII is highly specific for identification of primary and metastatic urothelial carcinomas. However, the sensitivity of UPIII in detection of urothelial carcinoma is moderate. Combined use of a panel of antibodies is important in the diagnosis of urothelial tumors.
