Hepatocellular Ca stained with anti-MDR1
The multidrug resistance protein 1 (MDR-1), also known as P-glycoprotein 1(PgP), is a conserved plasma membrane protein that functions as an ATP-dependent efflux pump with broad specificity. MDR-1 expression is thought to cause cross-resistance to structurally unrelated anti-cancer drugs, which may decrease intracellular drug concentrations. MDR-1 is typically expressed primarily in regions that act as epithelial barriers or perform excretory function in the liver, kidney, gastrointestinal tract, and the blood-brain barrier. In tumors,MDR-1 is widely expressed in many human cancers, commonly found in colon cancer, renal cancer,hepatocellular carcinoma and hematopoietic malignanacies.
The multidrug resistance protein 1 (MDR-1), also known as P-glycoprotein 1(PgP), is a conserved plasma membrane protein that functions as an ATP-dependent efflux pump with broad specificity. MDR-1 expression is thought to cause cross-resistance to structurally unrelated anti-cancer drugs, which may decrease intracellular drug concentrations. MDR-1 is typically expressed primarily in regions that act as epithelial barriers or perform excretory function in the liver, kidney, gastrointestinal tract, and the blood-brain barrier. In tumors,MDR-1 is widely expressed in many human cancers, commonly found in colon cancer, renal cancer,hepatocellular carcinoma and hematopoietic malignanacies.
