Breast Ca stained with Anti-CK8 & CK18 Cocktail
Cytokeratin 8 (CK8) is an intermediate filament protein produced early in embryogenesis. It is the only type-II CK occurring in many simple epithelial cells in respiratory, gastrointestinal, male and female reproductive tracts, and thyroid. CK8 is often co-expressed with Cytokeratin 18 (CK18). CK8/18 is the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine. The CK8 antibody is used to detect adenocarcinomas of simple epithelium origin. The difference in staining pattern is useful to distinguish ductal (peripheral staining) from lobular (perinuclear staining) breast carcinoma. Cytokeratin 18 is an intermediate filament phosphoglycoprotein that is expressed in simple and glandular and transitional epithelial cells, but not in stratified epithelial cells.
Cytokeratin 8 (CK8) is an intermediate filament protein produced early in embryogenesis. It is the only type-II CK occurring in many simple epithelial cells in respiratory, gastrointestinal, male and female reproductive tracts, and thyroid. CK8 is often co-expressed with Cytokeratin 18 (CK18). CK8/18 is the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine. The CK8 antibody is used to detect adenocarcinomas of simple epithelium origin. The difference in staining pattern is useful to distinguish ductal (peripheral staining) from lobular (perinuclear staining) breast carcinoma. Cytokeratin 18 is an intermediate filament phosphoglycoprotein that is expressed in simple and glandular and transitional epithelial cells, but not in stratified epithelial cells.
