Tonsil stained with Anti-CD95
The CD95(Fas) protein is a cell surface receptor belonging to the tumor necrosis factor(TNF) family that transduces death signaling on engagement by multimeric Fas ligand(CD95L), of which there are eight in its membrane-bound form or in its soulble form resulting from cleavage by a putative metalloproteinase. CD95 is a widely expressed protein. CD95 mediated apoptosis is an essential mechanism for the maintenance of normal tissue homeostasis and disruption of its death pathway has been associated with a wide range of human diseases, including autoimmune diseases, lymphoproliferative disorders and malignancies. The Fa death system also plays important roles in various apoptosis conditions such as those evoked by irradiation, chemotherapeutic agents and viral infections. The expression of CD95 serves as a prognostic marker in predicting the outcome of disease progression and treatment in many types of tumors
The CD95(Fas) protein is a cell surface receptor belonging to the tumor necrosis factor(TNF) family that transduces death signaling on engagement by multimeric Fas ligand(CD95L), of which there are eight in its membrane-bound form or in its soulble form resulting from cleavage by a putative metalloproteinase. CD95 is a widely expressed protein. CD95 mediated apoptosis is an essential mechanism for the maintenance of normal tissue homeostasis and disruption of its death pathway has been associated with a wide range of human diseases, including autoimmune diseases, lymphoproliferative disorders and malignancies. The Fa death system also plays important roles in various apoptosis conditions such as those evoked by irradiation, chemotherapeutic agents and viral infections. The expression of CD95 serves as a prognostic marker in predicting the outcome of disease progression and treatment in many types of tumors
