Tonsil Stained with Anti-CD3
CD3 protein is a T-cell marker, a complex composed of 4 membrane glycoprotein subtypes, including extracellular, transmembrane and intracellular domains. The CD3 complex is responsible for mediating the process of transferring the activation signal generated by the TCR recognition antigen to the cell, mediating the proliferation of T cells and the release of cytokines. CD3 is only found in T cells. In malignant lymphoma, CD3 is a widespread T cell line-restricted antigen, which can be detected in 80%-97% of T-cell lymphomas. Mature T-cell lymphomas may lose CD3 abnormally, such as mycosis fungoides, peripheral T-cell lymphoma, and anaplastic large-cell lymphoma. CD3 is an important marker for the classification of malignant lymphoma and lymphoid leukemia.
CD3 protein is a T-cell marker, a complex composed of 4 membrane glycoprotein subtypes, including extracellular, transmembrane and intracellular domains. The CD3 complex is responsible for mediating the process of transferring the activation signal generated by the TCR recognition antigen to the cell, mediating the proliferation of T cells and the release of cytokines. CD3 is only found in T cells. In malignant lymphoma, CD3 is a widespread T cell line-restricted antigen, which can be detected in 80%-97% of T-cell lymphomas. Mature T-cell lymphomas may lose CD3 abnormally, such as mycosis fungoides, peripheral T-cell lymphoma, and anaplastic large-cell lymphoma. CD3 is an important marker for the classification of malignant lymphoma and lymphoid leukemia.
