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Fibrous Histiocytoma stained with Anti-CD248(Endosialin)
CD248, known also as endosialin and tumor endothelial marker 1(TEM1) , is a 95-kDa transmembrane glycoprotein expressed in activated stromal and perivescular fibroblasts and pericytes. CD248 is an important regulator of critical pathways involved with stromal fibroblast migration,and proliferation. During normal embroyonic development,CD248 is highly expressed across diverse tissue types. Postnatally, its expression is restricted to the endometrium,bone marrow and corpus luteum. In vitro protein structure studies demonstrated interaction of the extracellular domain of CD248 with extracellular matrix proteins, Facilitating cell migration and metastatic formation. conversely,the cytoplasmic domain was shown to regulate stromal fibroblast function. CD248 is expressed within the endothelium across many tumors types include sarcomas , carcinomas and neuroectodermal tumors.within the tumor stroma , activated fibroblasts subpopulations are often associated with poor prognosis.
CD248, known also as endosialin and tumor endothelial marker 1(TEM1) , is a 95-kDa transmembrane glycoprotein expressed in activated stromal and perivescular fibroblasts and pericytes. CD248 is an important regulator of critical pathways involved with stromal fibroblast migration,and proliferation. During normal embroyonic development,CD248 is highly expressed across diverse tissue types. Postnatally, its expression is restricted to the endometrium,bone marrow and corpus luteum. In vitro protein structure studies demonstrated interaction of the extracellular domain of CD248 with extracellular matrix proteins, Facilitating cell migration and metastatic formation. conversely,the cytoplasmic domain was shown to regulate stromal fibroblast function. CD248 is expressed within the endothelium across many tumors types include sarcomas , carcinomas and neuroectodermal tumors.within the tumor stroma , activated fibroblasts subpopulations are often associated with poor prognosis.
