Tonsil stained with anti-CD105
CD105(endoglin) is a disulfide-linked homodimeric cell membrane glycoprotein. It was initially discovered in a human pre-B cell line. CD105 functions as a receptor for transforming growth factor(TGF)-β1 and β3, and modulates TGF-β signaling through interactions with TGF-β receptors I and/or II. CD105 is a proliferation-associated and hypoxia inducible protein abundantly expressed in angiogenic endothelial cells. Tumor microvessel density assessed by CD105 immunohistochemical staining in paraffin-embedded tissue sections correlates significantly with tumor aggressiveness and prognosis in many types of solid tumors.
CD105(endoglin) is a disulfide-linked homodimeric cell membrane glycoprotein. It was initially discovered in a human pre-B cell line. CD105 functions as a receptor for transforming growth factor(TGF)-β1 and β3, and modulates TGF-β signaling through interactions with TGF-β receptors I and/or II. CD105 is a proliferation-associated and hypoxia inducible protein abundantly expressed in angiogenic endothelial cells. Tumor microvessel density assessed by CD105 immunohistochemical staining in paraffin-embedded tissue sections correlates significantly with tumor aggressiveness and prognosis in many types of solid tumors.
