Tonsil stained with Anti-CD10
CD10 is a single-chain cell surface glycoprotein, also designated as common acute lymphoblastic leukemia antigen (CALLA), neprilysin and neutral endopeptidase. Besides, CD10 is a zinc dependent peptidase (metalloprotease), degrading various bioactive peptides, and it plays a functional role by modulating cellular responses to peptide substrates. CD10 is present on the cell surface of bone marrow stem cells and myelopoietic cells (including neutrophils), follicular centre cells, few mature B-lymphocytes, and a subpopulation of parafollicular T-lymphocytes. CD10 is also found in enterocytes in the upper part of the intestinal tract (brush border), in liver(bile canaliculi),kidney (glomerular and proximal tubular cells), pulmonary alveolar cells, myoepithelial cells of breast and sweat and salivary glands, prostate glandular cells, placental trophoblastic cells, endometrial stromal cells, some hematopoietic tumors and chronic myelogenous leukemias in lymphoid blast crisis. CD10 is particularly useful in the classification of B-cell leukemias/ lymphomas and classification of carcinomas (identification of hepatocellular carcinoma and renal cell carcinoma). CD10 may be used in the identification of metaplastic breast carcinoma, prognostication of breast carcinoma and classification of uterine mesenchymal neoplasms (identification of stromal sarcoma).
CD10 is a single-chain cell surface glycoprotein, also designated as common acute lymphoblastic leukemia antigen (CALLA), neprilysin and neutral endopeptidase. Besides, CD10 is a zinc dependent peptidase (metalloprotease), degrading various bioactive peptides, and it plays a functional role by modulating cellular responses to peptide substrates. CD10 is present on the cell surface of bone marrow stem cells and myelopoietic cells (including neutrophils), follicular centre cells, few mature B-lymphocytes, and a subpopulation of parafollicular T-lymphocytes. CD10 is also found in enterocytes in the upper part of the intestinal tract (brush border), in liver(bile canaliculi),kidney (glomerular and proximal tubular cells), pulmonary alveolar cells, myoepithelial cells of breast and sweat and salivary glands, prostate glandular cells, placental trophoblastic cells, endometrial stromal cells, some hematopoietic tumors and chronic myelogenous leukemias in lymphoid blast crisis. CD10 is particularly useful in the classification of B-cell leukemias/ lymphomas and classification of carcinomas (identification of hepatocellular carcinoma and renal cell carcinoma). CD10 may be used in the identification of metaplastic breast carcinoma, prognostication of breast carcinoma and classification of uterine mesenchymal neoplasms (identification of stromal sarcoma).
